What Medications Make Gastroparesis Worse?
Gastroparesis, a condition where the stomach takes longer than normal to empty its contents, can significantly impact a person’s quality of life. While there is no cure for this chronic digestive disorder, managing symptoms is crucial. One aspect of managing gastroparesis involves being aware of certain medications that can exacerbate the condition. This article explores what medications make gastroparesis worse and provides insights into safer alternatives.
Anticholinergic Medications
Anticholinergic medications are commonly prescribed for various conditions, including allergies, overactive bladder, and Parkinson’s disease. However, these drugs can worsen gastroparesis symptoms. They work by blocking the action of acetylcholine, a neurotransmitter that stimulates the muscles of the stomach to contract and empty its contents. As a result, anticholinergic medications can slow down the stomach’s emptying process, leading to increased discomfort and nausea.
Some examples of anticholinergic medications include:
– Atropine: Often used for the treatment of gastrointestinal spasms and as a component of some eye drops.
– Scopolamine: Commonly found in motion sickness medications like Dramamine.
– Hyoscyamine: Used to treat various gastrointestinal disorders, such as irritable bowel syndrome (IBS).
Antidepressants
Antidepressants, particularly tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), can also worsen gastroparesis symptoms. These medications are known to affect the stomach’s motility, leading to delayed emptying and increased symptoms.
Some examples of antidepressants that may exacerbate gastroparesis include:
– Amoxapine
– Clomipramine
– Desipramine
– Imipramine
– Nortriptyline
– Paroxetine
– Sertraline
Antihistamines
Antihistamines are commonly used to treat allergies and hay fever. However, some antihistamines can worsen gastroparesis symptoms by slowing down the stomach’s emptying process.
Some examples of antihistamines that may exacerbate gastroparesis include:
– Cetirizine
– Diphenhydramine
– Fexofenadine
– Hydroxyzine
Alternatives and Considerations
If you have gastroparesis and are currently taking any of the medications mentioned above, it is essential to consult with your healthcare provider. They may recommend alternative medications or adjust your dosage to minimize the impact on your condition.
Some safer alternatives for managing symptoms include:
– Histamine H2 receptor antagonists: These medications, such as ranitidine and famotidine, are less likely to worsen gastroparesis symptoms compared to antihistamines.
– Prokinetic agents: These drugs, such as metoclopramide and erythromycin, can help improve stomach motility and may be beneficial for some individuals with gastroparesis.
Conclusion
Understanding which medications make gastroparesis worse is crucial for managing the condition effectively. By working closely with your healthcare provider, you can find the right balance of medications to alleviate symptoms while minimizing the risk of exacerbating your gastroparesis.
